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date title
11/12/08
referral award  not applied
  Phage Display Scientist
Merck Serono
Geneva

Phage Display Scientist
A vacancy exists for a Phage Display Scientist in the Protein Engineering and Antibody Technologies Department (PEAT) at the Geneva Research Centre, which focuses on the discovery and development of fully human therapeutic antibodies against neurodegenerative and autoimmune disease targets. The successful candidate will work on several therapeutic antibody programs from early discovery to development stage.

Main Tasks & Responsibilities :
Design and execute target-specific selection strategies using phage display antibody libraries
Library panning and screening
Responsible for expression, purification and biochemical/biophysical characterization of FAbs
Develop new protocols addressing different target classes
Design and implement affinity maturation strategies
Keep up to date with current phage display technology innovations, and advance phage display technologies within his/her own group
Qualifications: Bachelors Degree
Doctorate
Experience: 5 years +
Languages: English : Speak / Write Fluently
Job-Type: open-ended
Remuneration: unspecified
Permit Type: International
Region: Geneva
PhD in molecular biology, biochemistry, biotechnology or biological sciences
Fluency in English
Professional Skills & Experience :
A minimum of 5 years postdoctoral experience in an academic or industrial setting
Strong background in molecular biology
Experience in antibody phage display technology and affinity maturation strategies are essential
Experience with high throughput screening methodologies, automated systems for the multi-round workflow of picking, re-arraying of positives and 'cherry picking' of unique clones, antibody sequence analysis tools and database management is required
Experience in the design and building of new phage display libraries is desirable
Familiarity with techniques for biochemical and biophysical characterization of FAbs and IgGs (ELISA, FACS, Biacore, DSC, HPLC, Kinexa ) would be useful.
Previous experience in the preclinical development of therapeutic antibodies is desirable
Personal Skills & Competencies :
Highly motivated and pro-active
Able to multi-task and work to strict deadlines
Excellent organizational and communication skills
Good team player
Aptitude to work in a pluri-cultural environment

Merck Serono is the division for innovative small molecules and biopharmaceuticals of Merck KGaA.
Merck Serono’s global headquarters are located in Geneva, Switzerland.

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